Parametri kvaliteta plodova kod različitih genotipova paradajza u organskoj proizvodnji

The aim of this study was to examine the content of total soluble solids, organic acids and lycopene in fruits of different tomato genotypes grown in organic production. Four different genotypes (Volovsko heart Red cherry, Tigrella and Viva) were used during this experiment. The quality of tomato fruits was analyzed based on the measurement of total soluble solids, organic acids and lycopene in fresh weight of the fruit. The values obtained for the analyzed parameters of fruit quality were as follows: total soluble solids 4.98, 5.26, 5.28 and 4.70 (° Brix), organic acids 160.67, 110.34, 132.77 and 116 (citric acid µmol g-1 FW), lycopene, 8.22, 5.70, 7.61, 9.21 (mg kg-1 FW) in genotypes Volovsko srce, Red cherry, Tigrella and Viva. Oscillations in the obtained parameters, especially in the content of lycopene in different genotypes were probably the result of genetic resources, but also the influence of abiotic factors.Cilj ovog istraživanja je bio da se ispita sadržaj ukupnih rastvorljivih suvih materija, organskih kiselina i likopena u plodovima različitih genotipova paradajza gajenog u organskoj proizvodnji. Četiri različita genotipa (Volovsko srce, Red cherry, Tigrella i Viva) su korišćeni tokom ovog eksperimenta. Kvalitet plodova paradajza analiziran je na osnovu merenja ukupnih rastvorljivih suvih materija, organskih kiselina i likopena u svežoj masi plodova. Dobijene vrednosti za analizirane parametre kvaliteta plodova su iznosile: ukupne rastvorljive materije 4.98, 5.26, 5.28 i 4.70 (oBrix), organske kiseline 160.67, 110.34, 116 i 132.77 (citric acid µmol g-1 FW), likopen 8.22, 5.70, 7.61, 9.21 (mg kg-1 FW) kod analiziranih genotipova Volovsko srce, Red cherry, Tigrella i Viva. Variranje u dobijenim parametrima, a naročito u sadržaju likopena kod različitih genotipova su bile posledica genetskog potencijala, ali i uticaja abiotičkih faktora

KARAPANDZIC FLAP FOR RECONSTRUCTION OF LOWER LIP IN A 18-MONTH OLD BOY WITH CONGENITAL AGAMMAGLOBULINEMIA AND ECTHYMA GANGRENOSUM. CASE REPORT

The reconstruction of lower lip in children is extremely rare and challenging procedure. The etiology in literature reveals trauma and infection. An 18-month boy was admitted with sepsis and pneumonia. Laboratory tests revealed congenital agammaglobulinemia. Necrosis of lower lip developed and was diagnosed as ecthyma gangrenosum. Blood culture was positive for Pseudomonas aeruginosa. Multiple abscess formations were found in abdominal wall and gluteal region and were treated by incisions. After spontaneous demarcation of necrotic tissue in lower lip the Karapandzic flap technique was used for reconstruction. Karapandzic flap can be used as optimal method for reconstruction of lower lip in children with satisfactory functional and aesthetic results.Key words: Karapandzic flap, ecthyma gangrenosum, reconstructio

IL-33 Prevents MLD-STZ Induction of Diabetes and Attenuate Insulitis in Prediabetic NOD Mice

Type 1 diabetes is an autoimmune disease caused by the immune-mediated destruction of pancreatic β-cells. Prevention of type 1 diabetes requires early intervention in the autoimmune process against beta-cells of the pancreatic islets of Langerhans, which is believed to result from disordered immunoregulation. CD4+Foxp3+ regulatory T cells (Tregs) participate as one of the most important cell types in limiting the autoimmune process. The aim of this study was to investigate the effect of exogenous IL-33 in multiple low dose streptozotocin (MLD-STZ) induced diabetes and to delineate its role in the induction of protective Tregs in an autoimmune attack. C57BL/6 mice were treated i. p. with five doses of 40 mg/kg STZ and 0.4 μg rIL-33 four times, starting from day 0, 6, or 12 every second day from the day of disease induction. 16 weeks old NOD mice were treated with 6 injections of 0.4 μg/mouse IL-33 (every second day). Glycemia and glycosuria were measured and histological parameters in pancreatic islets were evaluated at the end of experiments. Cellular make up of the pancreatic lymph nodes and islets were evaluated by flow cytometry. IL-33 given simultaneously with the application of STZ completely prevented the development of hyperglycemia, glycosuria and profoundly attenuated mononuclear cell infiltration. IL-33 treatment was accompanied by higher number of IL-13 and IL-5 producing CD4+ T cells and increased presence of ST2+Foxp3+ regulatory T cells in pancreatic lymph nodes and islets. Elimination of Tregs abrogated protective effect of IL-33. We provide evidence that exogenous IL-33 completely prevents the development of T cell mediated inflammation in pancreatic islets and consecutive development of diabetes in C57BL/6 mice by facilitating the induction Treg cells. To extend this finding for possible relevance in spontaneous diabetes, we showed that IL-33 attenuate insulitis in prediabetic NOD mice

Risk factors for infections caused by carbapenem-resistant Enterobacterales: an international matched case-control-control study (EURECA)

Cases were patients with complicated urinary tract infection (cUTI), complicated intraabdominal (cIAI), pneumonia or bacteraemia from other sources (BSI-OS) due to CRE; control groups were patients with infection caused by carbapenem-susceptible Enterobacterales (CSE), and by non-infected patients, respectively. Matching criteria included type of infection for CSE group, ward and duration of hospital admission. Conditional logistic regression was used to identify risk factors. Findings Overall, 235 CRE case patients, 235 CSE controls and 705 non-infected controls were included. The CRE infections were cUTI (133, 56.7%), pneumonia (44, 18.7%), cIAI and BSI-OS (29, 12.3% each). Carbapenemase genes were found in 228 isolates: OXA-48/like, 112 (47.6%), KPC, 84 (35.7%), and metallo-beta-lactamases, 44 (18.7%); 13 produced two. The risk factors for CRE infection in both type of controls were (adjusted OR for CSE controls; 95% CI; p value) previous colonisation/infection by CRE (6.94; 2.74-15.53; <0.001), urinary catheter (1.78; 1.03-3.07; 0.038) and exposure to broad spectrum antibiotics, as categorical (2.20; 1.25-3.88; 0.006) and time-dependent (1.04 per day; 1.00-1.07; 0.014); chronic renal failure (2.81; 1.40-5.64; 0.004) and admission from home (0.44; 0.23-0.85; 0.014) were significant only for CSE controls. Subgroup analyses provided similar results. Interpretation The main risk factors for CRE infections in hospitals with high incidence included previous coloni-zation, urinary catheter and exposure to broad spectrum antibiotics

EuReCa ONE—27 Nations, ONE Europe, ONE Registry A prospective one month analysis of out-of-hospital cardiac arrest outcomes in 27 countries in Europe

AbstractIntroductionThe aim of the EuReCa ONE study was to determine the incidence, process, and outcome for out of hospital cardiac arrest (OHCA) throughout Europe.MethodsThis was an international, prospective, multi-centre one-month study. Patients who suffered an OHCA during October 2014 who were attended and/or treated by an Emergency Medical Service (EMS) were eligible for inclusion in the study. Data were extracted from national, regional or local registries.ResultsData on 10,682 confirmed OHCAs from 248 regions in 27 countries, covering an estimated population of 174 million. In 7146 (66%) cases, CPR was started by a bystander or by the EMS. The incidence of CPR attempts ranged from 19.0 to 104.0 per 100,000 population per year. 1735 had ROSC on arrival at hospital (25.2%), Overall, 662/6414 (10.3%) in all cases with CPR attempted survived for at least 30 days or to hospital discharge.ConclusionThe results of EuReCa ONE highlight that OHCA is still a major public health problem accounting for a substantial number of deaths in Europe.EuReCa ONE very clearly demonstrates marked differences in the processes for data collection and reported outcomes following OHCA all over Europe. Using these data and analyses, different countries, regions, systems, and concepts can benchmark themselves and may learn from each other to further improve survival following one of our major health care events

Invariance of statistical causality under convergence

In this paper we prove the invariance of some causality relationships between flows of information (represented by filtrations) under some types of convergence. We consider a statistical concept of causality which is based on Granger's definition of causality, but instead of time series we focus on continuous time processes.Causality Filtration Conditional independence Weak convergence

SOCIAL DISTANCE AND THE STRUCTURE OF STEREOTYPES OF PRIMARY SCHOOL STUDENTS TOWARDS ROMA: QUANTITATIVE AND QUALITATIVE ANALYSIS

Social distance has been the subject of numerous research papers; the issue of researching social distance toward Roma is especially important. There are several aims of our study. The basic goal of the research is to determine the existence and intensity of social distance towards Roma held by primary school students. The specific goal of the research is to determine the differences in the presence of social distance held by students who often interact with Roma children, as well as those who rarely interact with them. The research sample consisted of 152 participants (71 fourth-grade students and 81 eighth-grade students; 85 boys and 67 girls). The Bogardus’s Scale, modified for children, was used for researching the social distance. Furthermore, the research implied two focus groups for the qualitative data to be obtained. The results showed the existance of social distance toward Roma students. Furthermore, according to this data, the least desirable relationship was sitting in the same school bench with Roma children, whereas the most acceptable relationship was going to the same school with Roma. Moreover, it was established that students having more relationships with Roma had lower social distance toward them as well. Qualitative data analysis shows higher level of negative stereotypes and attitudes toward Roma. It is essential to combine quantitative and qualitative measures for the purpose of getting the unbiased description of social distance toward Roma.Publishe